New bronchodilators and combinations in COPD treatment
نویسندگان
چکیده
منابع مشابه
Pharmacology of bronchodilators used in the treatment of COPD.
Anticholinergics have been used as bronchodilators for several hundred years in western Europe (7). They act by blocking the effects of acetylcholine, which is released from parasympathetic nerves in the airways, and which contributes to bronchoconstriction and mucus secretion in patients with COPD. Acetylcholine causes activation of muscarinic receptors at the level of the target cells, such a...
متن کاملCost effectiveness of therapy with combinations of long acting bronchodilators and inhaled steroids for treatment of COPD.
BACKGROUND Little is known about the combination of different medications in chronic obstructive pulmonary disease (COPD). This study determined the cost effectiveness of adding salmeterol (S) or fluticasone/salmeterol (FS) to tiotropium (T) for COPD. METHODS This concurrent, prospective, economic analysis was based on costs and health outcomes from a 52 week randomised study comparing: (1) T...
متن کاملBronchodilators use in patients with COPD
BACKGROUND Bronchodilators are commonly used as maintenance and rescue therapy in patients with COPD. We aimed to examine the prescribing patterns of bronchodilators in clinical practice. METHODS We identified patients with COPD who initiated oral or inhaled bronchodilators between 2001 and 2010 from the Taiwan National Health Insurance Research Database. We followed the patients for 1 year. ...
متن کاملNew combinations in the treatment of COPD: rationale for aclidinium–formoterol
The current guidelines on chronic obstructive pulmonary disease (COPD) recommend the prominent use of bronchodilators, including long-acting β2-agonists (LABAs) and long-acting muscarinic antagonists (LAMAs), while inhaled corticosteroids are recommended only in patients with severe disease or frequent exacerbations. LABA-LAMA combinations are indicated when single bronchodilators are insuffici...
متن کاملA new user cohort study comparing the safety of long-acting inhaled bronchodilators in COPD
OBJECTIVE To investigate a possible increased risk observed in tiotropium clinical trials of stroke and other adverse events. DESIGN New users of long-acting anticholinergic therapy (tiotropium HandiHaler®) were compared with new users of long-acting β-agonist (LABA) monotherapy, and propensity scores were used to control confounding. SETTING UK healthcare system general practitioner electr...
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ژورنال
عنوان ژورنال: Tuberkuloz ve Toraks
سال: 2016
ISSN: 0494-1373
DOI: 10.5578/tt.10267